Patients with episodic migraines (EM) with cyclic phenotype experience increasing headaches over time; however, appropriate preventive treatment may modulate this cyclic nature.
Why this matters
Migraines occur at varying intensities and frequencies and can be categorized as chronic (CM; 15 or more headaches monthly) or episodic. However, the association between migraine fluctuations and progression over time is not well defined.
Sinusoidal models can be fitted to headache behavior to help to identify cyclic phenotypes in certain migraine patients.
Understanding the natural history of migraines or when to start preventative treatment could help clinicians better manage patients with migraine disorders and improve quality of life.