Analgesic drug use and headache fluctuations in migraine sufferers – how does this affect disease progression?


  • Patients with episodic migraines (EM) with cyclic phenotype experience increasing headaches over time; however, appropriate preventive treatment may modulate this cyclic nature.

Why this matters

  • Migraines occur at varying intensities and frequencies and can be categorized as chronic (CM; 15 or more headaches monthly) or episodic. However, the association between migraine fluctuations and progression over time is not well defined.

  • Sinusoidal models can be fitted to headache behavior to help to identify cyclic phenotypes in certain migraine patients.

  • Understanding the natural history of migraines or when to start preventative treatment could help clinicians better manage patients with migraine disorders and improve quality of life.