Cardiovascular risk factors in late life may be inversely associated with risk of incident dementia


  • Older individuals with low values for systolic blood pressure, BMI, or non-high-density lipoprotein (HDL) cholesterol have a higher dementia risk compared to individuals without any low values. Dementia risk is substantially higher in individuals with low values for all three risk factors.

Why this matters

  • U-shaped associations have been described between a variety of cardiovascular risk factors and dementia in late life. The exact nature of these associations, and whether these risk factors have an additive effect remain unclear.

  • Observing these risk factors could help clinicians to identify older individuals at increased risk for cognitive decline and dementia. This may contribute to developing new prediction models and future guidelines.