Dietary spermidine supplementation does not improve cognition in older adults with subjective cognitive decline


  • Dietary spermidine supplementation over 12 months provides no significant benefits on mnemonic discrimination performance in older adults with subjective cognitive decline.

Why this matters?

  • There is an urgent need for interventions against age-related memory decline; animal studies have indicated that spermidine supplementation confers beneficial effects on brain and cognitive health.

  • This phase 2b trial assessed whether longer-term supplementation with a 10% increased daily supply of spermidine improved memory performance in adults with subjective cognitive decline; the results suggest that increasing dietary spermidine will not improve memory or other biomarkers in older adults at risk of Alzheimer’s disease.