Examining the association between physical frailty and structural brain changes in cognitively unimpaired individuals


  • Physical frailty components, slowness and weakness, were associated with changes to brain structure (total brain volume, hippocampal volume, and white matter hypointensities) in cognitively unimpaired older individuals.

Why this matters

  • Physical frailty is associated with cognitive decline and dementia.

  • The underlying mechanism of developing dementia in people with physical frailty is not well understood and a greater understanding could lead to personalized approaches for treating such patients.