Genetic frontotemporal dementia: decoding its motor phenotypes

Takeaway

  • In genetic cases of frontotemporal dementia (FTD), multiple natural clusters of motor signs are present, each correlating with specific brain atrophy patterns. Their motor severity depends on time to expected onset and the affected gene.

Why this matters

  • Motor disorders are increasingly recognized as part of the clinical spectrum of FTD, yet detailed phenotypic characterization on motor features is lacking.

  • These genetic associations can help to guide diagnostic evaluations, clinical decision making, and the development of disease-modifying or preventive treatments.