Gut microbiota analysis in pediatric-onset multiple sclerosis


  • In a Dutch pediatric-onset multiple sclerosis (MS) cohort, gut microbiota composition and predicted functional features do not significantly differ between patients with pediatric-onset MS, monophasic acquired demyelinating syndromes (mADS), and healthy controls.

Why this matters

  • There has been increasing interest in the role of the gut–brain axis and gut microbiota in the pathogenesis of MS. Pediatric-onset MS provides a unique opportunity to study the etiology of MS with minimal confounding factors.

  • This sheds light on the complex role of the gut microbiota in MS which still requires further investigation. BMI and its probable link to gut microbiota and MS is a potential treatment target.