Predicting chronic pain in patients with mild acute traumatic brain injury


  • Functional connectivity features obtained shortly after mild traumatic brain injury can predict its transition to chronic pain, which may be due to injury-related primary sensorimotor cortical areas interacting with the mesolimbic and pain modulation systems.

Why this matters

  • The transition from acute to chronic pain is prevalent and difficult to predict, particularly in patients with mild traumatic brain injury; however, the nucleus accumbens and periaqueductal gray matter are regions of interest for chronic pain.

  • If chronic pain can be better predicted in patients with mild traumatic brain injury, then a predictive marker may be identified for future early preventative treatments.