Understanding gait impairment in hereditary spastic paraplegia using a mobile gait analysis system

Takeaway

  • Gait impairment cyclicity parameters in hereditary spastic paraplegia (HSP) can be captured using wearable sensors and correlate with clinical sequelae such as disease severity and gait-related quality of life.

Why this matters?

  • HSP is group of rare genetic diseases with wide variability in age of onset, rate of progression, and clinical phenotypes. Progressive lower limb spasticity and weakness are common clinical hallmarks across HSP. Over time, this leads to gait disorder and, for many, loss of ambulation.

  • To date, there has been a lack of understanding surrounding the feasibility and clinical potential of gait parameters in HSP patients. Determining correlation between gait parameters and clinical scores offers another mechanism to assess HSP, subsequently increasing clinical understanding of longitudinal changes in gait in HSP and its associated outcomes.